Hurler Syndrome
Growth in Hurler syndrome is significantly less than normal. Babies
with Hurler syndrome grow normally during the first year of life. However,
growth slows down by the end of the first year, and usually stops by
age 3. The final height of most people with Hurler syndrome is less
than 4 feet tall. People with Hurler syndrome also appear disproportioned,
with their trunks relatively shorter than their legs.
All people with Hurler syndrome have problems with bone formation and
growth. The term for this combination of bone problems is dysostosis
multiplex, which includes some or all of the following: an abnormally
shaped skull, curvature of the spine, unstable neck bones, dislocated
hips, joint stiffness, and short, broad hands with bent fingers. Some
of these abnormalities are strictly cosmetic; others may interfere with
movement or cause pain or significant health problems.
Some bone abnormalities may require surgery or other treatment to prevent
serious complications. A referral to an orthopedic surgeon may be done
to assess bone issues and appropriate management. Joint pain may be relieved
with painkillers and/or anti-inflammatory medications.
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