Fueling Scientific
Inquiry and Innovation
01.23.06
Aerobic glycolysis in cancerOn Research Day, January 11, the Millberry Union Gymnasium was packed
with students, their mentors and families, and nearly one hundred student research posters
demonstrating, in Dean Kessler's words, "a range of topics that reflects
the diversity of interests on our campus and supports our strong conviction
that first-rate science comes in a variety of flavors."
The dean also commended the faculty mentors for their dedication. He cited as an example Dr. Dan Lowenstein by noting how often, on the way home late in the
evening, he would spy "Dan at a table in the Food Court, still
working with a student on a science project."
On his part, Dr. Lowenstein pointed out that the research opportunities provided by the school were meant to not only help students learn more about the world of biomedical research, but to also gain a deeper appreciation for the way scientific discoveries ultimately have an impact on day-to-day clinical care.
People who are ill usually come to us with three basic and almost universal questions: Why I am sick? When will I get better? What can you do to help me? My hope is that experiences in research can help students see that our ability to answer these three questions is directly linked to progress in medical science and is firmly rooted in the efforts of individuals with skeptical, inquiring and innovative minds.
-- Daniel Lowenstein, MD |
Four students were awarded the Dean's Prize in Research and had the opportunity to present their work (shown below, with comments by their sponsors.)
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Structure-Function Analysis of Homeodomain Interacting
Protein Kinase 2 (HIPK2) Inhibition of the Wnt/Beta-catenin
Signaling Pathway
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"This mechanism will undoubtedly become
a new and powerful therapeutic target for a variety of human
cancers."
-- Eric Huang, MD, PhD
Sponsor, Dept. of Pathology |
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Proton-sensing mechanisms in the immune system: A role
for the T cell death-associated gene 8
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"The involvement of TDAG8 in this process
provides insight into the molecular mechanisms that govern
immune cell responses and may lead to novel therapeutic approaches
targeted to this receptor."
-- Owen Witte, MD
Sponsor, Dept. of Microbiology, Immunology, and Molecular
Genetics at UCLA |
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Multiparameter Flow Cytometric Analysis Reveals Aberrant Activation
of Signaling Molecules in Defined Populations of Kras Mutant
Bone Marrow
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"Assays of this type will be essential
to measure the effects of treatments that target 'cancer stem
cells' in leukemia and other malignancies. "
-- Kevin Shannon, MD
Sponsor, Dept. of Pediatrics |
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The Predictive Value of Specific Mammographic Findings
in Breast Cancer Detection
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"I believe Aruna's results will lead towards concrete improvements in the way mammograms are interpreted."
-- Rebecca Smith-Bindman, MD
Sponsor, Dept. of Radiology
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Photos: Sarah Paris
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