Pathways to Discovery
Clinical and Translational Research
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Molecular Medicine
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Current Courses

 

Pathway to Discovery in Molecular Medicine

Contacts

 

Robert Nussbaum, MD, Director
Professor of Medicine (Medical Genetics)
nussbaumr@humgen.ucsf.edu
415-476-3200

Harold Bernstein, MD, PhD, Associate Director

Professor of Pediatrics (Cardiology)

harold.bernstein@ucsf.edu

415-502-8633


Molecular Medicine Faculty
Faculty/Email
Title
Research Interests
Harold Bernstein, MD, PhD Professor, Pediatrics and CVRI

cell cycle regulation, stem cell biology, cell signaling, muscle biology, myocardial regeneration, heart failure website

Robert Nussbaum, MD Professor, Medicine and Genetics

Human molecular genetics, Parkinson's disease, Mouse models website

Professor Chair, Pathology

cell cycle regulation, stem cell biology, cell signaling, muscle biology, myocardial regeneration, heart failure website

Nadav Ahituv, PhD
Asst. Professor Biopharmaceutical Science and IHG human genetics, genomics, gene regulation, limb malformations, obesity, pharmacogenomics, enhancer, mouse models, zebrafis website
Mark S. Anderson, MD, PhD
Asst. Professor Diabetes autoimmunity, immune tolerance, thymic selection website
Sergio E. Baranzini, PhD
Adj. Asst. Professor, Neurology
Gladstone Institute
systems biology, multiple sclerosis genetics/genomics, gene expression/bioinformatics, experimental neuroimmunology, mathematical/statistical modeling website
Diane L. Barber, PhD
Professor and Vice Chair, Cell and Tissue Biology cell migration, cancer, metastasis, turmorigenesis, actin cytoskeleton, intracellular pH, epithelial to mesenchymal transition (EMT) website
Michael S. Beattie, PhD
Professor, Neurological Surgery neural injury and repair, regeneration, spinal cord injury, apoptosis, stem cell transplantation, recovery of neurological function, cell death, de- and remyelination website
Daniel D. Bikle, MD, PhD

Professor, Endocrine vitamin D and calcium regulation of keratinocyte differentiation; role of IGF-I in the anabolic response of bone to mechanical load and parathyroid hormone website
Harold A. Chapman, MD
Professor, Medicine and Pulmonary interstitial lung disease and pulmonary fibrosis, integrin signaling in lung cancer, epithelial mesenchymal transition pathways of TGFβ1 signaling website
Shweta Choudhry, PhD

Asst. Adjunct Professor, Lung Biology asthma, COPD, interstitial lung diseases, diabetes, cardiovascular disease, metabolic, syndrome, complex diseases, population genetics, molecular genetics, pharmacogenetics, admixture, admixture mapping, population stratification, understudied populations, race/ethnicity, candidate gene, studies, genome-wide association studies, gene-environment interactions, gene-gene interaction, pathway analysis
website
Céline I. Colnot, Ph.D

Asst. Professor, Orthopaedic Surgery Cartilage and Bone Biology, Developmental Biology, Skeletal Repair and Regeneration, Cellular and Molecular Biology, Skeletal Stem Cells, In vivo Cell Lineage Analysis, Angiogenesis, Inflammation, Extracellular Matrix Remodeling website
Bruce R. Conklin, MD
Sr. Investigator Gladstone Institute of Cardiovascular Disease, Professor, UCSF Department of Medicine, Division of Medical Genetics Signaling, Hormones, G protein coupled receptors, stem cells, cardiac, bioinformatics website
Michael Salvatore Conte, MD
Chief, Vascular Surgery vascular injury, vein bypass graft, angioplasty, gene therapy, smooth muscle cells website
Heike E. Daldrup-Link, MD, PhD
Associate Professor, Radiology and Pediatrics

imaging, molecular imaging, cellular imaging, cell tracking radiology website
BMS website

Jayanta Debnath, MD
Assistant Professor, Pathology autophagy, apoptosis, oncogenes, breast cancer, three-dimensional culture, epithelial cancersextracellular matrix, integrins, ubiquitin-like molecules website
David Erle, MD
Professor, Medicine asthma, immunology, genomics, gene regulation, DNA microarrays, micro-RNA website
Donna M. Ferriero, MD
Professor, Neurology and Pediatrics brain development, newborn brain injury, excitotoxicity, hypoxia inducible genes, neuroprotection website
Howard L. Fields, MD, PhD

Professor, Neurology and Physiology alcoholism and drug addiction, neuroscience of motivation website
James A. Frank, MD

Associate Professor, Medicine acute lung injury, acute respiratory distress syndrome, pulmonary edema, ion transport, permeability, tight junction, alveolar epithelium, pulmonary fibrosis, sepsis, lung cancer website
Fen-Biao Gao, PhD

Associate Professor, Neurology frontotemporal dementia, neurodegeneration, microRNAs website
Michael S. German, MD

Professor, Diabetes Center diabetes mellitus, insulin, carbohydrate metabolism, pancreas, islets of Langerhans, beta-cells, developmental, biology, stem cell, biology, regeneration, gene expression, transcription factors, microRNA, genomics
website

Linda Giudice, MD, PhD, MSc

Professor and Ob/Gyn Chair, Ob/Gyn and Reproductive Sciences

human reproduction, functional genomics, steroid hormone action, endocrine disruptors, mucosal immunity, ovarian cancer, stem, cells, translational science website

Su Guo, PhD

Associate Professor, Biopharmaceutical Sciences neuroscience, developmental biology, stem cells, Parkinson's disease, genetics, dopamine biology, behavior website

Nalin Gupta, MD, PhD

Associate Professor, Neurological Surgery and Pediatrics

pediatric brain tumors, macrophage infiltration, drug delivery, mouse models website

Jiang He, PhD
Assistant Professor, Radiology molecular imaging, drug targeting and drug delivery, nanotechnology, peptide, antibody discovery; radiotracer, radiopharmaceutics, radiotherapy, nuclear imaging; angiogenesis, breast cancer, prostate cancer, pancreatic cancer website
Michelle Hermiston, MD, PhD

Asst. Professor, Pediatrics

signal transduction, phosphatase, mouse models of benign and malignant hematologic disease, leukemia, lymphoma, phospho-flow cytometry, macrophage activation syndrome, lupus, autoimmunity, tolerance, dendritic cell, B cell, homeostasis website

Katherine M. Hyland, PhD

Associate Professor, Biochemistry and Biophysics Professional Courses Co-Director website

Ajay N. Jain, PhD

Professor, Cancer Research Institute molecular docking, molecular similarity, ligand-based activity modeling, organism-scale multi-target prediction of biological activity, and computational approaches to rationalizing pharmacology website

Ella Fung Jones, PhD

Asst. Professor, Radiology molecular imaging, optical imaging, multi-modality imaging, contrast agents development for X-ray and optical imaging, in vivo monitoring of protease activities, disease progression, drug dosage response, targeted imaging website
Ophir David Klein, MD, PhD

Assistant Professor, Orofacial Surgery stem cells, developmental biology, regenerative medicine, craniofacial biology, bone biology website
Scott Kogan, MD
Associate Professor, Laboratory Medicine leukemia, hematopoiesis, cancer stem cells, carcinogenesis website
Arnold R. Kriegstein, MD, PhD
Director, Institute for Regeneration Medicine cortical development, neural stem cells, neural progenitor cells, neurogenesis, radial glia, neuronal migration, developmental neurobiology, neurophysiology website
Deanna L. Kroetz, PhD

Professor, Biopharmaceutical Sciences pharmacogenetics, drug netabolism, drug transporters, renal cytochrome P450 eicosanoid
website
Jennifer LaVail, PhD
Professor, Anatomy and Ophthalmology neurobiology, virology, herpetic infections of the brain, axonal transport website
Patricia A. Leake, PhD

Professor, Otolaryngology - Head and Neck Surgery cochlear implants, auditory system development, plasticity, neurotrophins website
Andrew D. Leavitt, MD

Professor, Laboratory Medicine and Medicine
Medical Director, Adult Blood and Marrow Transplant Laboratory
human embryonic stem cells, hematopoietic stem cells, thrombopoietin/MPL signaling website
Randall J. Lee, MD, PhD

Professor, Cardiology, Section of Electrophysiology tissue engineering, myocardial regeneration, stem cells, antibodies website
Jay A. Levy, MD
Professor, Hematology/Oncology HIVAIDS, immunology, cell biology website
Long-Cheng Li, MD

Assistant Professor, Urology RNA activation, gene regulation, small RNA and cancer website
Daniel A. Lim, MD, PhD
Asst. Professor, Neurosurgery stem cells, adult neurogenesis, chromatin remodeling, epigenetics, cell transplantation, gene therapy, stereotactic neurosurgery, MRI-guided neurosurgery, neurodegenerative disease, Parkinson's disease, demyelinating diseases website
Tippi C. MacKenzie, MD
Asst. Professor of Surgery stem cell transplantation, tolerance induction, fetal and neonatal immunity, fetal therapy website
Sharmila Majumdar, PhD
Professor and Vice Chair, Radiology radiology, magnetic resonance imaging, image processing,computer-assisted, osteoporosis, osteoarthritis, osteoarthritis, knee, osteoarthritis, hip, imaging, bioengineering, cartilage, bone, inter-vertebral disc, musculoskeletal website
Ralph S. Marcucio, PhD
Asst. Professor, Orthopaedic Surgery craniofacial development, structural birth defects, Shh, Fgf, Bmp, Wnt, neural crest, skeletal repair, stem cell therapy, trauma website
Carol Anne Mathews, MD
Assoc. Professor, Psychiatry genetics, psychopathology, phenomenology, endophenotypes, psychiatric disorders of childhood, genetic epidemiology website
Michael A. Matthay, MD
Professor, Medicine and Anesthesia mesenchymal stem cells, lung fluid balance, acute lung injury, transport of salt, water and protein by the pulmonary epithelium website
Martin McMahon, PhD
Professor, Cancer Research Institute RAF kinases; MAP kinase signaling; mouse models of human cancer; Cell cycle regulation; apoptosis; experimental therapeutics website
Michael T. McManus, PhD
Assistant Professor, Diabetes Center RNA interference, microRNAs, development, genetics, mouse models, noncoding RNAs website
Patrick S. McQuillen, MD

Assoc. Professor, Pediatrics Critical Care developmental neuroscience, early hypoxic ischemic brain injury, selective vulnerability, plasticity, repair, regeneration, visual system, congenital heart disease, magnetic resonance imaging, neurodevelopmental, outcome, neuroprotection website
Robert O. Messing, MD
Professor, Neurology substance abuse, anxiety, pain, neuronal signal transduction, protein, kinase C, GABAA receptor, corticotrophin releasing hormone, neuropeptide Y, voltage-gated calcium channels, gene targeting, RNA interference, electrophysiology, behavioral pharmacology website

Theodore Miclau, MD

Professor, Orthopaedic Surgery fracture, repair, molecular and cellular events, inflammation, angiogenesis, bone, and cartilage website
Robert A. Nissenson, PhD
Professor, Medicine and Physiology control of bone mass by G protein signaling in osteoblasts; molecular determinants of osteoblast differentiation; role of G protein signaling in mesenchymal stem cell fate decisions; interplay between the anabolic effects of parathyroid hormone and canonical Wnt signaling in osteoblasts website
Douglas F. Nixon, MD, PhD
Professor, Medicine HIV, immunity, T cells, endogenous retroelements, HTLV-1, mycobacterium tuberculosis, NK, NKT website
Linda J. Noble, PhD

Professor, Neurological Surgery matrix metalloproteinases, oxidative stress, CNS trauma website
Scott Oakes, MD

Assistant Professor, Pathology

biochemistry of apoptosis, BCL-2 family, endoplasmic reticulum stress, myeloma, neurodegenerative disease website

Jorge R. Oksenberg, PhD

Professor, Neurology biochemistry of apoptosis, BCL-2 family, endoplasmic reticulum stress, myeloma, neurodegenerative disease
website
Joel M. Palefsky, MD

Professor, Laboratory Medicine and Medicine human papillomavirus, human immunodeficiency virus, Epstein Barr virus, anogenital cancer, anogenital intraepithelial neoplasia website
Boris Matija Peterlin, MD

Professor, Medicine, Microbiolology and Immunology acquired and congenital immunodeficiencies, HIV/AIDS, immunotherapy of cancer, models of autoimmunity: transcription of MHC class II genes, antigen processing and presentation; replication of HIV, latency, mechanism of action of viral accessory genes; control of elongation of transcription in health and disease; global health website
Samuel J. Pleasure, MD, PhD

Associate Professor, Neurology brain development; dentate gyrus; migration; Wnts; chemokines; retinoic, acid; meninges website
Louis J. Ptácek, MD

Professor, Neurology episodic disorders, epilepsy, migraine, circadian rhythm genetics, pathophysiology, animal modeling, human genetics website
Jennifer M. Puck, MD

Professor, Immunology primary immunodeficiency (PID), translational research, mouse models, newborn screening, immunology, genetics, gene therapy, severe combined immunodeficiency (SCID), autoimmune lymphoproliferative, syndrome (ALPS), hyper-IgE syndrome, lymphocyte development website
Katherine A. Rauen, MD, PhD
Associate Professor, Pediatrics Genetics array CGH, cardio-facio-cutaneous syndrome, cancer genomics, cancer syndromes, Costello syndrome, constitutional chromosome aberrations, cytogenetics, congenital abnormalities, genetic medicine, medical education, neurofibromatosis 1, Noonan syndrome, prenatal genetics, Ras/MAPK pathway website
Dorit Ron, PhD

Associate Professor, Neurology molecular neurobiology of addiction, signal transduction website
Philip J. Rosenthal, MD

Professor, Infectious Diseases malaria, Plasmodium, parasitology, drug resistance, Africa, protease website
Mark A. Schumacher, MD, PhD

Associate Professor, Anesthesia TRPV1, VR1, capsaicin receptor, splice variant, NGF, promoter, nociceptor, pain, transcription factors website
Kevin S. Shannon, MD

Professor, Pediatrics, Hematology and Oncology myeloid leukemia, mouse models, Ras, targeted therapeutics
website

Robin Mark Shaw, MD, PhD

Assistant Professor, Medicine and Cardiology cardiac electrophysiology, ion channels, membrane protein,trafficking, congestive heart failure, arrythmia, sudden cardiac, death, microRNA, TIRF microscopy website
Dean Sheppard, MD Professor, Medicine, Lung molecular bases of common lung diseases, in vivo, biology of integrins website
Elliott. H. Sherr, MD, PhD
Assistant Professor, Neurology autism, epilepsy, cognitive disability, genetics, brain development, diffusion tensor imaging, corpus callosum website
Paul C. Simpson, MD
Professor, Cardiology drug discovery, adrenergic receptors, knockout and transgenic mouse models, human heart tissue bank, heart and vascular cell culture (human, mouse, rat), cardiovascular molecular and cellular biology and physiology, brain ischemia, GPCR signaling, heart disease, heart failure, cardiomyopathy, heart transplantion, Neurological disease, traumatic brain injury website
Anne Slavotinek, MD, PhD

Associate Professor, Clinical Pediatrics Genetics birth defects, malformations, multiple congenital anomaly syndromes, congenital diaphragmatic hernia, anophthalmia, genome sequencing, microarrays, in-situ hybridization, expression studies, morpholino studies website
Matthew L. Springer, PhD

Associate Professor, Cardiology angiogenesis, cardiac function, endothelial function, bone marrow cell therapy, gene therapy, endothelial progenitor cells, flavanols, second hand cigarette smoke website
Deepak Srivastava, MD
Director, Gladstone Institute Cardiovascular Disease microRNA, cardiac development, differentiation website
Didier Y. R. Stainier, PhD

Professor, Biochemistry vertebrate organ formation/cardiovascular development/endoderm, liver, pancreas and gut development and regeneration/stem cell differentiation/lipid transport and metabolism website
Raymond A. Swanson, MD

Professor, Neurology neuroscience, inflammation, mitochondria, oxidative stress, stroke, Parkinson's disease, DNA damage website
Christian Vaisse, MD. PhD

Associate Professor, Diabetes Research Center obesity, diabetes, human genetics, neural regulation of energy homeostasis, hypothalamus website
Zinaida S. Vexler, PhD

Associate Professor, Neurology stroke, neurodegeneration, inflammation, chemokine, protection, repair, neonate, MRI website

Thiennu H. Vu, MD, PhD

Associate Professor, Lung Biology Center lung development, lung vascular development, lung alveolar development, asthma, lung cancer, COPD, respiratory diseases, global health website
Zena Werb, PhD
Professor, Anatomy breast development, breast cancer, epithelial biology, tumor, microenvironment, tumor metastasis website
Paul J. Wolters, MD
Assistant Professor, Pulmonary and Critical Care mast cell, sepsis, pneumonia, IL-6, protease, fibrosis, matrix, remodeling, epithelial to mesenchymal transition, translational, research, Th2 cytokine website
Anthony Wynshaw-Boris, MD, PhD

Division Chief, Pediatrics Medical Genetics mouse models of human neurogenetic disease, neuronal migration defects, neurogenesis, neural tube closure, social behavior, autism website
Keith R. Yamamoto, PhD

Professor, Cellular and Molecular Pharmacology mouse models of human neurogenetic disease, neuronal migration defects, neurogenesis, neural tube closure, social behavior, autism website
Yerem Yeghiazarians, MD

Assistant Professor, Medicine stem cell (adult and embryonic), myocardial infarction, myocardial repair, vascular biology, basic, translational and clinical research website
Midori Yenari, MD
Associate Professor, Neurology stroke, cerebral ischemia, inflammation, microglia, stress proteins website

William L. Young, PhD


Professor, Anesthesia, Neurosurgery and Neurology neuroanesthesia, intracranial hemorrhage, brain arteriovenous malformations, intracranial aneurysm, cerebral hemodynamics website

 

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