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University of California, San Francisco |  |
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Clinical Research Robert C. Mackerise, M.D., Professor of Surgery • Inflammatory Lung Injury following major injury: One of the main areas of focus has been post-traumatic inflammatory lung injury. This collaborative research effort has continued, with new reports of the clinical syndrome of ARDS (ref # 63), the impact of ARDS on specific outcomes (ref # 62), and a recent report examining surrogate serum markers predictive of inflammatory lung injury. (ref # 65). The most recent work, still in preparation (Abstract, WIP ref # 3), attemps to link elements of inflammation with post-traumatic coagulopathy, and to better define the nature of early coagulopathy (pre-massive transfusion) that follows shock, traumatic brain injury, and major organ injury. • Ventilatory management of patients with ARDS (refs # 66,67). Technical clinical studies performed in ICU patients with ARDS that attempt to expand our understanding of “optimal” modes of lung protective ventilation (LPV) in the setting or acute lung injury. LPV strategies are one of the few, if not the only demonstrable intervention having an impact on the outcome from ARDS over the past 15 years. • Violence prevention recidivism (Abstracts/WIP ref # 1). Work in progress, this is part of an ongoing clinical and programmatic study that screens victims of youth violence & assesses the likelihood of recidivism. “High risk” patients are then referred into a program linking hospital services with post-discharge neighborhood/community services for violence prevention. A randomized study is being designed to compare recidivism outcomes with and without programmatic influence. |
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